Endothelin Receptor
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Endothelin Receptor Inhibitors
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Endothelin Receptor Agonists
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Endothelin Receptor Antagonists
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Endothelin Receptor Modulator
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Endothelin Receptor Control
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Endothelin Receptor Ligands
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Endothelin Receptor Related Products (95)
Related Products (95)
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ACT-373898
0 ImagesCat. No.: HY-135500CAS No.: 1433875-14-9ACT-373898 is an inactive carboxylic acid metabolite of Macitentan. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist.
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TA-0201
0 ImagesCat. No.: HY-124234CAS No.: 169679-53-2TA-0201 is a novel orally active, competitive, non-peptide endothelin receptor antagonist. TA-0201 antagonizes the specific binding of [125I]ET-1 to cloned human receptors of ETA and ETB with Ki values of 15 pM and 41 nM, respectively. TA-0201 inhibits the pressor response to the exogenous big ET-1.
![[Ala18] Endothelin-1, human](https://file.medchemexpress.com/product_pic/hy-p3610.gif "Click to View [Ala18] Endothelin-1, human Product Detail")
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ANP (1-30), frog
0 ImagesCat. No.: HY-P3762CAS No.: 309245-16-7ANP (1-30), frog is a peptide fragment of atrial natriuretic peptide derived from frog. ANP (1-30), frog has natriuretic, diuretic, and vasorelaxant effects.
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PD 145065
0 ImagesCat. No.: HY-105183CAS No.: 153049-49-1PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC50 value of 4 nM for the ETA receptor for rabbit renal artery vascular smooth muscle cells.
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SB234551
0 ImagesCat. No.: HY-101262CAS No.: 188257-69-4SB234551 is a selective endothelin ETA receptor antagonist. SB234551 can be used in the study of stroke model.
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Endothelin (16-21)
0 ImagesCat. No.: HY-P5769CAS No.: 121377-67-1Endothelin (16-21) is a selective ETB receptor agonist (EC50=228 nM in guinea-pig bronchus). Endothelin (16-21) can induce smooth muscle contraction. Endothelin (16-21) is promising for research of respiratory (e.g., asthma) and cardiovascular (e.g., hypertension) diseases.
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Big Endothelin-1 (22-38), human
0 ImagesCat. No.: HY-P3733CAS No.: 124932-61-2Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38).
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SM19712 free acid
0 ImagesCat. No.: HY-120148CAS No.: 194542-49-9SM19712 free acid is an orally active, selective endothelin converting enzyme (ECE) inhibitor. SM19712 free acid inhibits conversion of big ET-1 to ET-1. SM19712 free acid attenuates colonic angiogenesis, tissue injury, inflammation, without altering colon shortening or myeloperoxidase levels in mice. SM19712 free acid can be used for the research of inflammatory bowel disease (colitis), ischemic acute renal failure, acute myocardial infarction, and myocardial ischemia/reperfusion injury.
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[Asn18] Endothelin-1 (swine, human)
![[Asn18] Endothelin-1 (swine, human)](https://file.medchemexpress.com/product_pic/hy-p3615.gif "Click to View [Asn18] Endothelin-1 (swine, human) Product Detail")
0 ImagesCat. No.: HY-P3615CAS No.: 138716-98-0[Asn18] Endothelin-1 swine, human is a structural analogue of Endothelin 1 (swine, human) (HY-P0202), with the Asp amino acid at position 18 mutated to Asn. Endothelin 1 (swine, human) is a synthetic peptide with human and porcine endothelin 1 sequences and is a potent endogenous vasoconstrictor.
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Clazosentan (Standard)
0 ImagesSynonyms: Ro 61-1790 (Standard); VML 588 (Standard); AXV-034343 (Standard)Clazosentan (Standard) is the analytical standard of Clazosentan. This product is intended for research and analytical applications. Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction.
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CH-141
0 ImagesCat. No.: HY-126036CAS No.: 78279-88-6CH-141 is a peripheral vasodilator, that can be used in hypertension research.
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Ambrisentan (Standard)
0 ImagesSynonyms: BSF 208075 (Standard); LU 208075 (Standard)Ambrisentan (Standard) is the analytical standard of Ambrisentan. This product is intended for research and analytical applications. Ambrisentan is a selective ET type A receptor (ETAR) antagonist.
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A-127722
0 ImagesCat. No.: HY-114674CAS No.: 195704-72-4A-127722 is A 2, 4-dialarylpyrrolidine-3-carboxylic acid ETA selective endothelin receptor (ET receptor) antagonist with IC50 value of 0.36 nM.
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L-749329
0 ImagesCat. No.: HY-117644CAS No.: 159590-37-1Synonyms: (Rac)-L-754142L-749329 ((Rac)-L-754142) is an ETA and ETB receptor antagonist, with Kis of 0.062 nM and 2.25 nM for ETA and ETB respectively. L-749329 inhibits ET-1-stimulated signaling.
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Piperitenone oxide
0 ImagesPiperitenone oxide is an orally active monoterpene ketone. Piperitenone oxide can be isolated from the essential oils of plants belonging to Mentha x villosa and Ziziphora clinopodioides. Piperitenone oxide induces differentiation. Piperitenone oxide induces chromosome breakage damage, aneuploidy damage and DNA single-strand breaks. Piperitenone oxide reduces ET-1 levels. Piperitenone oxide exerts antihypertensive effects. Piperitenone oxide can be used in studies related to colon cancer.
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Sulfisoxazole (Standard)
0 ImagesSulfisoxazole (Standard) is the analytical standard of Sulfisoxazole. This product is intended for research and analytical applications. Sulfisoxazole (Sulfafurazole) is an orally active endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole is a sulfonamide antibacterial agent with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A.
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Zibotentan (Standard)
0 ImagesSynonyms: ZD4054 (Standard)Zibotentan (Standard) is the analytical standard of Zibotentan. This product is intended for research and analytical applications. Zibotentan (ZD4054) is a potent, selective and orally active endothelin A (ETA) receptor antagonist with a Ki of 13 nM. Zibotentan has no inhibitory effect on ETB. Zibotentan has anticancer effects and can be used for castration-resistant prostate cancer (CRPC) research.
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Atrasentan sodium
0 ImagesCat. No.: HY-114674ACAS No.: 178738-96-0Atrasentan sodium is an endothelin receptor antagonist with IC50 of 0.0551 nM for ETA.
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IRL 2500 (Standard)
0 ImagesCat. No.: HY-103460RCAS No.: 169545-27-1IRL 2500 (Standard) is the analytical standard of IRL 2500 (HY-103460). This product is intended for research and analytical applications. IRL 2500 is a potent Endothelin receptor antagonist. IRL 2500 shows IC50 values of 1.3 and 94 nM for ETB and ETA receptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.
